Culicine genomics.

In our recent review on genetic and physical mapping in mosquitoes, we discussed the future of mosquito genomics (Severson et al., 2001). We stated that reagents and methodologies were in place for fine-scale mapping in Culicidae and for map-based positional cloning in Aedes aegypti and Anopheles gambiae. We reported that an An. gambiae genome project had been initiated and predicted that there would be considerable gene information developed from the whole genome sequence of the paradigm dipteran, Drosophila melanogaster. We were confident in our prediction that the genomes of one or more mosquitoes would be sequenced in toto. Little did we know just how quickly culicid genomics would progress.